Endocrine Abstracts

We present an unusual case of painful gynaecomastia due to a large adrenocortical tumour secreting oestradiol and other steroid hormones.A 46 years old man presented with a 6 months history of progressive, painful gynaecomastia. He had no other specific symptoms and had previously been well. Alcohol intake was not excessive. Interestingly, his sister had presented with a phaeochromocytoma 2 years previously.Examination demonstrated...

A 70-year-old woman was referred to the endocrine clinic with recently diagnosed diabetes mellitus and poorly controlled systemic hypertension. At presentation she had clinical features of Cushing’s syndrome including central obesity, Cushingoid facies and marked proximal myopathy. BP was 220/190. Initial biochemistry revealed plasma sodium 140 mmol/l, potassium 3.6 mmol/l and creatinine 82 mmol/l. Overnight 1 mg dexamethasone suppression test revealed cortisol 1148 mmol/...

We present a case of Phaeochromocytoma co-secreting ACTH as a rare cause of Cushing’s syndrome. Our patient is a 49 year lady admitted acutely with sudden onset headache and severe hypertension. CT brain and CSF analysis were normal. Her urinary catecholamines were found to be elevated. Noradrenaline 709 and 972 nmol/ mmol of creatinine (ref range 0–48), Adrenaline 215 and 256 (ref range 0–10). CT abdomen revealed 4.2 cm left adrenal mass, MIBG scan confirmed ph...

A 48-year-old woman presented to her GP with polyuria and proximal muscle weakness. She was found to have newly developed hypertension at 180/96 and her serum potassium was 2.7 mmol/l. Lisinopril 40 mg od and Slow-K 1 tablet bd were started and she was referred for further investigation.On clinic review blood pressure was 188/110 supine and 190/110 standing. Serum sodium was 147 mmol/l, potassium 3.7 mmol/l and total bicarbonate 29 mmol/l. Her Lisinopril...

Objectives: To establish the proportion of patients locally with potentially significant thyroid pathology not receiving specialist endocrine input. To look at the management of hyperthyroid patients within the Endocrinology service.Patients and methods: Utilising the laboratory database, 121 patients identified (97 female, 24 male; age range 17–93 years, average 55 years) with TFTs suggesting hyperthyroidism (raised fT4/fT3, and/or suppressed TSH) ...